25TH ANNUAL CONFERENCE

MAKING THE CONNECTIONs BETWEEN THE BRAIN & SKULL AND CEREBRAL BLOOD VESSEL DAMAGE IN TBI

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When you think of connections in traumatic brain injury, you likely think of neuronal architecture and connectivity. But what about the connections between the brain and skull? What is their role in traumatic brain injury? Can they get damaged? And, if so, how might it influence the risk of traumatic brain injury from repetitive head trauma? In this presentation, we will explore the connections between the brain and the skull from a mechanics perspective to identify if these small microstructures contribute to the risk in traumatic brain injury.

Blood vessels are commonly damaged as a result of both accidental trauma and surgical manipulation, but little is known about the mechanics of this damage or how damage processes affect subsequent vessel function, particularly when damage is subtle. In both traumatic brain injury and balloon angioplasty, little attention is paid to vessel damage that doesn’t result in hemorrhage. The prevailing clinical approach is to assume that a vessel is fine if it isn’t bleeding. This strategy appears to be effective at a basic level, but our research shows that even minor damage significantly alters function. We anticipate that improved understanding of damage mechanisms and their effects on vessel function will stimulate much-needed progress in injury prevention and treatment and in the optimization of medical procedures that induce vascular damage.

After attending this presentation, you will leave able to:

1) Summarize the effects of brain and skull interactions on the biomechanical elements of brain injury; and,
2) Discuss the effects of brain injury forces on the brain vascular system and pathology.

*Submission of the conference evaluation form indicates your completion of the entire program.

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